Dr. Tom N. Grossmann
Professor of Organic Chemistry
Email: t.n.grossmann@vu.nl
ScopusID: 7003509298
ResearcherID: A-4175-2015
Curriculum Vitae
Department of Chemistry and
Pharmaceutical Sciences
Amsterdam Institute for
Molecules, Medicines and Systems
VU University Amsterdam
De Boelelaan 1108
1081 HZ Amsterdam, The Netherlands
Disclaimer/Impressum
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Our β-catenin targeting Wnt inhibitor NLS-StAx-h is now commercially availableBy grossmannlab on Sep 21, 2018Bio-techne is offering NLS-StAx-h (Cat. No. 6531), a potent β-catenin antagonist that inhibits Wnt-signaling.
Read more here: Dietrich et al., Cell Chem. Biol., 2017
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Article in Applied Microbiology and Biotechnology is onlineBy grossmannlab on Aug 27, 2018Congratulations to our colleagues from Molecular Toxicology! Great to be part of the team!
“Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners”
S Ortega Ugalde, CP de Koning, K Wallraven, B Bruyneel, NPE Vermeulen, TN Grossmann, W Bitter, JNM Commandeur, JC Vos* DOI: 10.1007/s00253-018-9299-4
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Article in the journal RNA is onlineBy grossmannlab on Aug 10, 2018“Protein-RNA interactions: Structural characteristics and hotspot amino acids”
DM Krüger, S Neubacher, TN Grossmann*, DOI: 10.1261/rna.066464.118
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Article in mBio accepted and available via bioRxivBy grossmannlab on Aug 8, 2018Congratulations to Jan Lowe (MCR Cambridge), Joen Luirink (VU Amsterdam) and their teams! Great collaboration!
“Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB”
D Kureisaite-Ciziene, A Varadajan, SH McLaughlin, M Glas, AM Sliva, R Luirink, C Mueller, T den Blaauwen, TN Grossmann, J Luirink*, J Löwe* DOI: 10.1128/mBio.01346-18; bioRxiv doi.org/10.1101/362335
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Our web server “PRI HotScore” is onlineBy grossmannlab on Aug 7, 2018Under https://pri-hotscore.labs.vu.nl you can upload atomic coordinates of protein-RNA complexes to identify potential amino acid hot spots in the interface.
Read more here: Krüger et al., RNA, 2018
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Article in Angewandte Chemie is onlineBy grossmannlab on May 30, 2018“In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme”
M Pelay-Gimeno, T Bange, S Hennig, TN Grossmann*, DOI: 10.1002/anie.201804506 (open access: PDF)
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Article in Osteoarthritis and Cartilage is onlineBy grossmannlab on Mar 21, 2018Congratulations to Jessi Bertrand and her team! We’re glad to see StAx peptides in action.
“Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage”
A Held, A Glas, L Dietrich, M Bollmann, K Brandstädter, TN Grossmann, CH Lohmann, T Pap, J Bertrand*, DOI: 10.1016/j.joca.2018.02.908
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Felix Paulußen joins our teamBy grossmannlab on Jan 15, 2018Welcome Felix – Congratulations for receiving the STAR PLUS fellowship!
All the best for your joint project with Joen Luirink (Molecular Microbiology) and Daan Geerke (Molecular Toxicology)!
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Merry Christmas!By grossmannlab on Dec 18, 2017All the best for the holidays and the New Year!
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Perspective in Cell Chemical Biology is onlineBy grossmannlab on Nov 17, 2017“The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein”
NM McLoughlin, C Mueller, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.10.009
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Article in Chemistry – A European Journal is onlineBy grossmannlab on Oct 20, 2017“Oligonucleotides with cationic backbone and their hybridization with DNA: Interplay of base pairing and electrostatic attraction”
B Schmidtgall, A Kuepper, M Meng, TN Grossmann*, C Ducho*, DOI: 10.1002/chem.201704338
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Article in the Journal of Medicinal Chemistry is onlineBy grossmannlab on Oct 14, 2017“Structure-based design of macrocyclic peptides that inhibit protein-protein interactions”
DM Krüger, A Glas, D Bier, N Pospiech, K Wallraven, L Dietrich, C Ottmann, O Koch,* S Hennig,* TN Grossmann*, DOI: 10.1021/acs.jmedchem.7b01221
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Communication in Chemistry – A European Journal is onlineBy grossmannlab on Aug 5, 2017This communication is featured on the inside cover.
“Increased conformational flexibility of a macrocycle‒receptor complex contributes to reduced dissociation rates”
A Glas, EC Wamhoff, DM Krüger, C Rademacher*, TN Grossmann*, DOI: 10.1002/chem.201702776
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Article in Cell Chemical Biology is onlineBy grossmannlab on Jul 27, 2017“Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets b-Catenin Protein-Protein Interactions”
L Dietrich, B Rathmer, K Ewan, T Bange, S Heinrichs, TC Dale, D Schade, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.06.013
We thank our collaborators for their contributions!!
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Congratulations to Laura DietrichBy grossmannlab on Jul 25, 2017Laura successfully defended her PhD thesis “Zellgängige Peptide zur Inhibition des Wnt/β-Catenin Signalwegs”.
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Our work was highlighted in the latest issue of EU ResearchBy grossmannlab on Jul 22, 2017Combining the best of small molecules and biologics (page 12)
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Article in Nature Communications is onlineBy grossmannlab on Mar 23, 2017Congratulations to the Dissmeyer and Flashman labs and thanks for having us onboard!
“Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets”
MD White, M Klecker, R Hopkinson, D Weits, C Mueller, C Naumann, R O’Neill, J Wickens, J Yang, JC Brooks-Bartlett, EF Garman, TN Grossmann, N Dissmeyer*, E Flashman*, DOI: 10.1101/ncomms14690
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Poster prizes for Kerstin Wallraven and Adrian GlasBy grossmannlab on Mar 22, 2017Congratulations to Kerstin and Adrian who recieved prizes for their proster presentations at the German Peptide Symposium!
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Review in Angewandte Chemie is onlineBy grossmannlab on Feb 10, 2017Congratulations to the entire AztraZeneca/MPI satellite team!
“New modalities for challanging targets in drug discovery”
E Valeur,* SM Gueret, H Adihou, R Gopalakrishnan, M Lemurell, H Waldmann, TN Grossmann, AT Plowright, DOI: 10.1002/anie.201611914
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Niall McLoughlin and Mathias Wendt (re)join our teamBy grossmannlab on Jan 2, 2017Welcome, Niall and Mathias! All the best for your PhD research!
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