Grossmann

Perspective in Nature Chemistry is online

“Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns” (PDF)

WS Horne*, TN Grossmann*, Nature Chem., DOI: 10.1038/s41557-020-0420-9

Thanks to Seth Horne from the University of Pittsburgh for the great collaboration!

Article featured as JOC supplementary Cover

Our article “In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability” (S Neubacher*, J Saya, A Amore, TN Grossmann, DOI: 10.1021/acs.joc.9b02490) was featured as supplementary cover in the special issue “Modern Peptide and Protein Chemistry” of the Journal of Organic Chemistry.

Welcome to VENI fellow Nick Pearce

Great to have Nick joining the group! He is supported by a VENI grant and will work on the multi-dataset analysis in cystal structure determination.

Article in Chemical Science is online

“Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility”

K Wallraven, FL Holmelin, A Glas, S Hennig, AI Frolov*, TN Grossmann* DOI: 10.1039/C9SC04705K

Thanks to our collaborators at AstraZeneca!

Enjoy the holidays and all the best for the New Year!!

Durable enzymes for a green economy

Amsterdam Science magazine issue #10 is out highlighting our INCYPRO technology and their application in biocatalysis. Here you’ll find the PDF of the article.

Article in the Journal of Organic Chemistry is online

“In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability”
S Neubacher*, J Saya, A Amore, TN Grossmann* DOI: 10.1021/acs.joc.9b02490

Communication in ChemBioChem is online

“Lipidated stapled peptides targeting the acyl binding protein UNC119”

PM Cromm, H. Adihou, S. Kapoor, M Vazquez-Chantada, P Davey, D Longmire, E Hennes, W Hofer, P Küchler, E Chiarparin, H Waldmann*, TN Grossmann* DOI: 10.1002/cbic.201900615

Thanks for the great contributions from collaborators at the Max Planck Institute in Dortmund and at AstraZeneca!

Article in Angewandte Chemie is online

“Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly”

S Jeganathan, M Wendt, S Kiehstaller, D. Brancaccio, A Kuepper, N Pospiech, A Carotenuto, E Novellino, S Hennig*, TN Grossmann* DOI: 10.1002/anie.20190790

Thanks to Diego Brancaccio and Alfonso Carotenuto at University of Naples for contributing NMR structures of bound peptides!

Physics2Market grant

We’ll receive the Physics2Market grant supporting our efforts to use the INCYPRO technology to increase stability of therapeutic target proteins for screening purposes. Thanks to IXA for the support!

Read more about INCYPRO here: Pelay-Gimeno et al., Angew. Chem., 2018 and Neubacher et al., BIOspektrum, 2019

Welcome to Alessia Amore and Alan Gerber

We’re happy Alessia and Alan join the team as senior scientists contributing with their expertise on protein chemistry and molecular biology, respectively!

Congratulations to Carolin Müller!

Caro successfully defended her PhD. It’s great to see our first group member graduating from Amsterdam.

Read more about Caro’s research here: Angew. Chem. Int. Ed., 57, 17079 –17083 (2018) – open access (PDF)

Article in BIOspektrum is online

BIOspektrum is featuring our protein stabilization technology and the INCYPRO team.

The article can be found here (German, open access: PDF). Read more about INCYPRO here: M Pelay-Gimeno et al., Angew. Chem., 2018

Nina-Louisa Efrém supported by the German Academic Scholarship Foundation

Nina was awarded a scholarship by the Studienstifung des deutschen Volkes. Congratulations!!

In her master project, Nina develops strategies to target protein-protein interactions in the Wnt signalling pathway. Read more about our Wnt-targteing efforts here: Dietrich et al., Cell Chem. Biol., 2017

Incircular website is online!

Our INCYPRO technology is now implemented by Incircular Biotechnologies to stabilize proteins and enzymes for biotechnological and biomedical applications.We are suppored by Innovation Exchange Amsterdam, the European Research Council (ERC Proof-of-Concept grant) and VU Universtity Amsterdam.

If you want to learn more about INCYPRO and its implemenation follow Saskia on twitter @SaskiaNeubacher and read here: Pelay-Gimeno et al., Angew. Chem., 2018 (open access: PDF).

Welcome to our new master students

We’re happy Shymaa Sayed (from ENS Paris-Saclay) as well as Nina-Louisa Efrém, Inez Koornneef, Brecht Ellenbroek and Steven Frölke (all from VU Amsterdam) join our group!

Jordy Saya joins our team

Jordy joins our group as a postdoc supporting the stabilization of peptide and protein structures.

ERC proof of concept grant

Our ERC Proof-of-Concept proposal has been selected for funding. This will support our efforts to pursue the valorization of INCYPRO.

Read more here: Pelay-Gimeno et al., Angew. Chem., 2018 and Vrije Universiteit Amsterdam

Article featured as Angewandte inside cover

Our article  “Coiled‐coil peptide beacon: A tuneable conformational switch for protein detection” (C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515) was featured as inside cover by Angewandte Chemie.