Grossmann

ERC proof of concept grant

Our ERC proof of concept proposal has been selected for funding. This will support our efforts to pursue the valorization of INCYPRO.

Read more here: Pelay-Gimeno et al., Angew. Chem., 2018 and Vrije Universiteit Amsterdam

Article featured as Angewandte inside cover

Our article  “Coiled‐coil peptide beacon: A tuneable conformational switch for protein detection” (C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515) was featured as inside cover by Angewandte Chemie.

Merry Christmas to everyone!

Congratulations to Arne Küpper!

Arne successfully defended his PhD. His work paves the way for our RNA-targeting efforts!

Article in Angewandte Chemie is online

“Coiled‐coil peptide beacon: A tuneable conformational switch for protein detection”

C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515

Simion Becker and Jaap Achten join the INCYPRO team

Simion and Jaap have a background in Science, Business & Innovation and will support our efforts regarding the commercialization of INCYPRO: In situ cyclization of proteins. Welcome!

Read more about INCYPRO here: M Pelay-Gimeno et al., Angew. Chem., 2018

Our β-catenin targeting Wnt inhibitor NLS-StAx-h is now commercially available

Bio-techne is offering NLS-StAx-h (Cat. No. 6531), a potent β-catenin antagonist that inhibits Wnt-signaling.

Read more here: Dietrich et al., Cell Chem. Biol., 2017

Article in Applied Microbiology and Biotechnology is online

Congratulations to our colleagues from Molecular Toxicology! Great to be part of the team!

“Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners”

S Ortega Ugalde, CP de Koning, K Wallraven, B Bruyneel, NPE Vermeulen, TN Grossmann, W Bitter, JNM Commandeur, JC Vos* DOI: 10.1007/s00253-018-9299-4

Article in the journal RNA is online

“Protein-RNA interactions: Structural characteristics and hotspot amino acids”

DM Krüger, S Neubacher, TN Grossmann*, DOI: 10.1261/rna.066464.118

Article in mBio accepted and available via bioRxiv

Congratulations to Jan Lowe (MCR Cambridge), Joen Luirink (VU Amsterdam) and their teams! Great collaboration!

“Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB”

D Kureisaite-Ciziene, A Varadajan, SH McLaughlin, M Glas, AM Sliva, R Luirink, C Mueller, T den Blaauwen, TN Grossmann, J Luirink*, J Löwe* DOI: 10.1128/mBio.01346-18; bioRxiv doi.org/10.1101/362335

Our web server “PRI HotScore” is online

Under https://pri-hotscore.labs.vu.nl you can upload atomic coordinates of protein-RNA complexes to identify potential amino acid hot spots in the interface.

Read more here: Krüger et al., RNA, 2018

Article in Angewandte Chemie is online

“In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme”

M Pelay-Gimeno, T Bange, S Hennig, TN Grossmann*, DOI: 10.1002/anie.201804506 (open access: PDF)

Article in Osteoarthritis and Cartilage is online

Congratulations to Jessi Bertrand and her team! We’re glad to see StAx peptides in action.

“Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage”

A Held, A Glas, L Dietrich, M Bollmann, K Brandstädter, TN Grossmann, CH Lohmann, T Pap, J Bertrand*, DOI: 10.1016/j.joca.2018.02.908

Felix Paulußen joins our team

Welcome Felix – Congratulations for receiving the STAR PLUS fellowship!

All the best for your joint project with Joen Luirink (Molecular Microbiology) and Daan Geerke (Molecular Toxicology)!

Merry Christmas!

All the best for the holidays and the New Year!

Perspective in Cell Chemical Biology is online

“The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein”

NM McLoughlin, C Mueller, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.10.009

Article in Chemistry – A European Journal is online

“Oligonucleotides with cationic backbone and their hybridization with DNA: Interplay of base pairing and electrostatic attraction”

B Schmidtgall, A Kuepper, M Meng, TN Grossmann*, C Ducho*, DOI: 10.1002/chem.201704338

Article in the Journal of Medicinal Chemistry is online

“Structure-based design of macrocyclic peptides that inhibit protein-protein interactions”

DM Krüger, A Glas, D Bier, N Pospiech, K Wallraven, L Dietrich, C Ottmann, O Koch,* S Hennig,* TN Grossmann*, DOI: 10.1021/acs.jmedchem.7b01221

Communication in Chemistry – A European Journal is online

This communication is featured on the inside cover.

“Increased conformational flexibility of a macrocycle‒receptor complex contributes to reduced dissociation rates”

A Glas, EC Wamhoff, DM Krüger, C Rademacher*, TN Grossmann*, DOI: 10.1002/chem.201702776