Dr. Tom N. Grossmann
Professor of Organic Chemistry
Email: t.n.grossmann@vu.nl
ScopusID: 7003509298
ResearcherID: A-4175-2015
Curriculum Vitae
Department of Chemistry and
Pharmaceutical Sciences
Amsterdam Institute for
Molecules, Medicines and Systems
VU University Amsterdam
De Boelelaan 1108
1081 HZ Amsterdam, The Netherlands
Disclaimer/Impressum
|
|
For more news see Twitter @TomNGrossmannBy grossmannlab on Dec 21, 2018https://twitter.com/TomNGrossmann
|
|
ERC proof of concept grantBy grossmannlab on Dec 21, 2018Our ERC proof of concept proposal has been selected for funding. This will support our efforts to pursue the valorization of INCYPRO.
Read more here: Pelay-Gimeno et al., Angew. Chem., 2018 and Vrije Universiteit Amsterdam
|
|
Article featured as Angewandte inside coverBy grossmannlab on Dec 19, 2018Our article “Coiled‐coil peptide beacon: A tuneable conformational switch for protein detection” (C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515) was featured as inside cover by Angewandte Chemie.
|
|
Merry Christmas to everyone!By grossmannlab on Dec 14, 2018 |
|
Congratulations to Arne Küpper!By grossmannlab on Dec 9, 2018Arne successfully defended his PhD. His work paves the way for our RNA-targeting efforts!
|
|
Article in Angewandte Chemie is onlineBy grossmannlab on Nov 9, 2018“Coiled‐coil peptide beacon: A tuneable conformational switch for protein detection”
C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515
|
|
Simion Becker and Jaap Achten join the INCYPRO teamBy grossmannlab on Oct 1, 2018Simion and Jaap have a background in Science, Business & Innovation and will support our efforts regarding the commercialization of INCYPRO: In situ cyclization of proteins. Welcome!
Read more about INCYPRO here: M Pelay-Gimeno et al., Angew. Chem., 2018
|
|
Our β-catenin targeting Wnt inhibitor NLS-StAx-h is now commercially availableBy grossmannlab on Sep 21, 2018Bio-techne is offering NLS-StAx-h (Cat. No. 6531), a potent β-catenin antagonist that inhibits Wnt-signaling.
Read more here: Dietrich et al., Cell Chem. Biol., 2017
|
|
Article in Applied Microbiology and Biotechnology is onlineBy grossmannlab on Aug 27, 2018Congratulations to our colleagues from Molecular Toxicology! Great to be part of the team!
“Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners”
S Ortega Ugalde, CP de Koning, K Wallraven, B Bruyneel, NPE Vermeulen, TN Grossmann, W Bitter, JNM Commandeur, JC Vos* DOI: 10.1007/s00253-018-9299-4
|
|
Article in the journal RNA is onlineBy grossmannlab on Aug 10, 2018“Protein-RNA interactions: Structural characteristics and hotspot amino acids”
DM Krüger, S Neubacher, TN Grossmann*, DOI: 10.1261/rna.066464.118
|
|
Article in mBio accepted and available via bioRxivBy grossmannlab on Aug 8, 2018Congratulations to Jan Lowe (MCR Cambridge), Joen Luirink (VU Amsterdam) and their teams! Great collaboration!
“Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB”
D Kureisaite-Ciziene, A Varadajan, SH McLaughlin, M Glas, AM Sliva, R Luirink, C Mueller, T den Blaauwen, TN Grossmann, J Luirink*, J Löwe* DOI: 10.1128/mBio.01346-18; bioRxiv doi.org/10.1101/362335
|
|
Our web server “PRI HotScore” is onlineBy grossmannlab on Aug 7, 2018Under https://pri-hotscore.labs.vu.nl you can upload atomic coordinates of protein-RNA complexes to identify potential amino acid hot spots in the interface.
Read more here: Krüger et al., RNA, 2018
|
|
Article in Angewandte Chemie is onlineBy grossmannlab on May 30, 2018“In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme”
M Pelay-Gimeno, T Bange, S Hennig, TN Grossmann*, DOI: 10.1002/anie.201804506 (open access: PDF)
|
|
Article in Osteoarthritis and Cartilage is onlineBy grossmannlab on Mar 21, 2018Congratulations to Jessi Bertrand and her team! We’re glad to see StAx peptides in action.
“Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage”
A Held, A Glas, L Dietrich, M Bollmann, K Brandstädter, TN Grossmann, CH Lohmann, T Pap, J Bertrand*, DOI: 10.1016/j.joca.2018.02.908
|
|
Felix Paulußen joins our teamBy grossmannlab on Jan 15, 2018Welcome Felix – Congratulations for receiving the STAR PLUS fellowship!
All the best for your joint project with Joen Luirink (Molecular Microbiology) and Daan Geerke (Molecular Toxicology)!
|
|
Merry Christmas!By grossmannlab on Dec 18, 2017All the best for the holidays and the New Year!
|
|
Perspective in Cell Chemical Biology is onlineBy grossmannlab on Nov 17, 2017“The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein”
NM McLoughlin, C Mueller, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.10.009
|
|
Article in Chemistry – A European Journal is onlineBy grossmannlab on Oct 20, 2017“Oligonucleotides with cationic backbone and their hybridization with DNA: Interplay of base pairing and electrostatic attraction”
B Schmidtgall, A Kuepper, M Meng, TN Grossmann*, C Ducho*, DOI: 10.1002/chem.201704338
|
|
Article in the Journal of Medicinal Chemistry is onlineBy grossmannlab on Oct 14, 2017“Structure-based design of macrocyclic peptides that inhibit protein-protein interactions”
DM Krüger, A Glas, D Bier, N Pospiech, K Wallraven, L Dietrich, C Ottmann, O Koch,* S Hennig,* TN Grossmann*, DOI: 10.1021/acs.jmedchem.7b01221
|
|
Communication in Chemistry – A European Journal is onlineBy grossmannlab on Aug 5, 2017This communication is featured on the inside cover.
“Increased conformational flexibility of a macrocycle‒receptor complex contributes to reduced dissociation rates”
A Glas, EC Wamhoff, DM Krüger, C Rademacher*, TN Grossmann*, DOI: 10.1002/chem.201702776
|
|