Dr. Tom N. Grossmann
Professor of Organic Chemistry
VU University Amsterdam
Dept. of Chemistry & Pharmaceutical Sci.
De Boelelaan 1108
1081 HZ Amsterdam
The Netherlands
Chemical Genomics Centre (CGC)
of the Max Planck Society
Otto-Hahn-Str. 15
44227 Dortmund
Germany
Email: t.n.grossmann@vu.nl
ResearcherID: A-4175-2015
Curriculum Vitae
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Article in Osteoarthritis and Cartilage is onlineBy grossmannlab on Mar 21, 2018Congratulations to Jessi Bertrand and her team! We’re glad to see StAx peptides in action.
“Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage”
A Held, A Glas, L Dietrich, M Bollmann, K Brandstädter, TN Grossmann, CH Lohmann, T Pap, J Bertrand*, DOI: 10.1016/j.joca.2018.02.908
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Felix Paulußen joins our teamBy grossmannlab on Jan 15, 2018Welcome Felix – Congratulations for receiving the STAR PLUS fellowship!
All the best for your joint project with Joen Luirink (Molecular Microbiology) and Daan Geerke (Molecular Toxicology)!
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Merry Christmas!By grossmannlab on Dec 18, 2017All the best for the holidays and the New Year!
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Perspective in Cell Chemical Biology is onlineBy grossmannlab on Nov 17, 2017“The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein”
NM McLoughlin, C Mueller, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.10.009
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Article in Chemistry – A European Journal is onlineBy grossmannlab on Oct 20, 2017“Oligonucleotides with cationic backbone and their hybridization with DNA: Interplay of base pairing and electrostatic attraction”
B Schmidtgall, A Kuepper, M Meng, TN Grossmann*, C Ducho*, DOI: 10.1002/chem.201704338
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Article in the Journal of Medicinal Chemistry is onlineBy grossmannlab on Oct 14, 2017“Structure-based design of macrocyclic peptides that inhibit protein-protein interactions”
DM Krüger, A Glas, D Bier, N Pospiech, K Wallraven, L Dietrich, C Ottmann, O Koch,* S Hennig,* TN Grossmann*, DOI: 10.1021/acs.jmedchem.7b01221
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Communication in Chemistry – A European Journal is onlineBy grossmannlab on Aug 5, 2017This communication is featured on the inside cover.
“Increased conformational flexibility of a macrocycle‒receptor complex contributes to reduced dissociation rates”
A Glas, EC Wamhoff, DM Krüger, C Rademacher*, TN Grossmann*, DOI: 10.1002/chem.201702776
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Article in Cell Chemical Biology is onlineBy grossmannlab on Jul 27, 2017“Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets b-Catenin Protein-Protein Interactions”
L Dietrich, B Rathmer, K Ewan, T Bange, S Heinrichs, TC Dale, D Schade, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.06.013
We thank our collaborators for their contributions!!
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Congratulations to Laura DietrichBy grossmannlab on Jul 25, 2017Laura successfully defended her PhD thesis “Zellgängige Peptide zur Inhibition des Wnt/β-Catenin Signalwegs”.
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Our work was highlighted in the latest issue of EU ResearchBy grossmannlab on Jul 22, 2017Combining the best of small molecules and biologics (page 12)
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Article in Nature Communications is onlineBy grossmannlab on Mar 23, 2017Congratulations to the Dissmeyer and Flashman labs and thanks for having us onboard!
“Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets”
MD White, M Klecker, R Hopkinson, D Weits, C Mueller, C Naumann, R O’Neill, J Wickens, J Yang, JC Brooks-Bartlett, EF Garman, TN Grossmann, N Dissmeyer*, E Flashman*, DOI: 10.1101/ncomms14690
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Poster prizes for Kerstin Wallraven and Adrian GlasBy grossmannlab on Mar 22, 2017Congratulations to Kerstin and Adrian who recieved prizes for their proster presentations at the German Peptide Symposium!
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Review in Angewandte Chemie is onlineBy grossmannlab on Feb 10, 2017Congratulations to the entire AztraZeneca/MPI satellite team!
“New modalities for challanging targets in drug discovery”
E Valeur,* SM Gueret, H Adihou, R Gopalakrishnan, M Lemurell, H Waldmann, TN Grossmann, AT Plowright, DOI: 10.1002/anie.201611914
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Niall McLoughlin and Mathias Wendt (re)join our teamBy grossmannlab on Jan 2, 2017Welcome, Niall and Mathias! All the best for your PhD research!
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Article in ACS Chemical Biology is onlineBy grossmannlab on Dec 21, 2016“Translocation of an intracellular protein via peptide-directed ligation”
C Stiller, DM Krüger, N Brauckhoff, M Schmidt, P Janning, H Salamon, TN Grossmann*, DOI: 10.1021/acschembio.6b01013
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Merry Christmas!By grossmannlab on Dec 20, 2016We wish you a merry Christmas and a happy New Year!
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Congratulations to Christiane StillerBy grossmannlab on Dec 8, 2016Christiane successfully defended her PhD thesis “Peptid-vermittelte chemische Modifikation intrazellulärer Proteine”.
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Congratulations to Adrian GlasBy grossmannlab on Sep 22, 2016Adrian successfully defended his PhD thesis “Kohlenwasserstoffverbrückte Peptide mit irregulärer Sekundärstruktur für die Inhibition von Protein-Protein-Interaktionen”.
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Communication in ChemBioChem is onlineBy grossmannlab on Sep 6, 2016“Constraining an irregular peptide secondary structure through ring-closing alkyne metathesis”
PM Cromm, K Wallraven, A Glas, D Bier, A Fürstner, C Ottmann, TN Grossmann*, DOI: 10.1002/cbic.201600362
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Congratulations to Philipp CrommBy grossmannlab on Jun 28, 2016Philipp successfully defended his PhD thesis “Design und Synthese Peptid-basierter Inhibitoren für Protein-Protein-Interaktionen”.
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