Grossmann

Congratulations to Carolin Müller!

Caro successfully defended her PhD. It’s great to see our first group member graduating from Amsterdam.

Read more about Caro’s research here: Angew. Chem. Int. Ed., 57, 17079 –17083 (2018) – open access (PDF)

Article in BIOspektrum is online

BIOspektrum is featuring our protein stabilization technology and the INCYPRO team.

The article can be found here (German, open access: PDF). Read more about INCYPRO here: M Pelay-Gimeno et al., Angew. Chem., 2018

Nina-Louisa Efrém supported by the German Academic Scholarship Foundation

Nina was awarded a scholarship by the Studienstifung des deutschen Volkes. Congratulations!!

In her master project, Nina develops strategies to target protein-protein interactions in the Wnt signalling pathway. Read more about our Wnt-targteing efforts here: Dietrich et al., Cell Chem. Biol., 2017

Incircular website is online!

Our INCYPRO technology is now implemented by Incircular Biotechnologies to stabilize proteins and enzymes for biotechnological and biomedical applications.We are suppored by Innovation Exchange Amsterdam, the European Research Council (ERC Proof-of-Concept grant) and VU Universtity Amsterdam.

If you want to learn more about INCYPRO and its implemenation follow Saskia on twitter @SaskiaNeubacher and read here: Pelay-Gimeno et al., Angew. Chem., 2018 (open access: PDF).

Welcome to our new master students

We’re happy Shymaa Sayed (from ENS Paris-Saclay) as well as Nina-Louisa Efrém, Inez Koornneef, Brecht Ellenbroek and Steven Frölke (all from VU Amsterdam) join our group!

Jordy Saya joins our team

Jordy joins our group as a postdoc supporting the stabilization of peptide and protein structures.

ERC proof of concept grant

Our ERC Proof-of-Concept proposal has been selected for funding. This will support our efforts to pursue the valorization of INCYPRO.

Read more here: Pelay-Gimeno et al., Angew. Chem., 2018 and Vrije Universiteit Amsterdam

Article featured as Angewandte inside cover

Our article  “Coiled‐coil peptide beacon: A tuneable conformational switch for protein detection” (C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515) was featured as inside cover by Angewandte Chemie.

Merry Christmas to everyone!

Congratulations to Arne Küpper!

Arne successfully defended his PhD. His work paves the way for our RNA-targeting efforts!

Article in Angewandte Chemie is online

“Coiled‐coil peptide beacon: A tuneable conformational switch for protein detection”

C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515

Simion Becker and Jaap Achten join the INCYPRO team

Simion and Jaap have a background in Science, Business & Innovation and will support our efforts regarding the commercialization of INCYPRO: In situ cyclization of proteins. Welcome!

Read more about INCYPRO here: M Pelay-Gimeno et al., Angew. Chem., 2018

Our β-catenin targeting Wnt inhibitor NLS-StAx-h is now commercially available

Bio-techne is offering NLS-StAx-h (Cat. No. 6531), a potent β-catenin antagonist that inhibits Wnt-signaling.

Read more here: Dietrich et al., Cell Chem. Biol., 2017

Article in Applied Microbiology and Biotechnology is online

Congratulations to our colleagues from Molecular Toxicology! Great to be part of the team!

“Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners”

S Ortega Ugalde, CP de Koning, K Wallraven, B Bruyneel, NPE Vermeulen, TN Grossmann, W Bitter, JNM Commandeur, JC Vos* DOI: 10.1007/s00253-018-9299-4

Article in the journal RNA is online

“Protein-RNA interactions: Structural characteristics and hotspot amino acids”

DM Krüger, S Neubacher, TN Grossmann*, DOI: 10.1261/rna.066464.118

Article in mBio accepted and available via bioRxiv

Congratulations to Jan Lowe (MCR Cambridge), Joen Luirink (VU Amsterdam) and their teams! Great collaboration!

“Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB”

D Kureisaite-Ciziene, A Varadajan, SH McLaughlin, M Glas, AM Sliva, R Luirink, C Mueller, T den Blaauwen, TN Grossmann, J Luirink*, J Löwe* DOI: 10.1128/mBio.01346-18; bioRxiv doi.org/10.1101/362335

Our web server “PRI HotScore” is online

Under https://pri-hotscore.labs.vu.nl you can upload atomic coordinates of protein-RNA complexes to identify potential amino acid hot spots in the interface.

Read more here: Krüger et al., RNA, 2018

Article in Angewandte Chemie is online

“In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme”

M Pelay-Gimeno, T Bange, S Hennig, TN Grossmann*, DOI: 10.1002/anie.201804506 (open access: PDF)

Article in Osteoarthritis and Cartilage is online

Congratulations to Jessi Bertrand and her team! We’re glad to see StAx peptides in action.

“Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage”

A Held, A Glas, L Dietrich, M Bollmann, K Brandstädter, TN Grossmann, CH Lohmann, T Pap, J Bertrand*, DOI: 10.1016/j.joca.2018.02.908